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European Directorate for the Quality of Medicines and HealthCare
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Octapharma ag
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CSL Behring
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Octapharma ag
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Intersero GmbH
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CSL Behring
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Esoterix Genetic Laboratories
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CSL Behring
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Intersero GmbH
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Image Search Results
Journal: Transfusion Medicine and Hemotherapy
Article Title: Components in Plasma-Derived Factor VIII, But Not in Recombinant Factor VIII Downregulate Anti-Inflammatory Surface Marker CD163 in Human Macrophages through Release of CXCL4 (Platelet Factor 4)
doi: 10.1159/000472157
Figure Lengend Snippet: Some plasma-derived factor VIII products augment agonist-induced platelet fibrinogen binding. Platelets were incubated with 0.5-2 U/ml of the indicated factor VIII product and 3 µmol/l melagatran for 1 h and then activated with ADP for 5 min in the presence of fibrinogen-FITC. After fixation, cells were washed and analyzed by flow cytometry. Data show mean ± standard deviation (SD) from 3 independent experiments. ADP = adenosine diphosphate; FITC = fluorescein isothiocyanate.
Article Snippet: The same three plasma-derived FVIII concentrates that enhanced
Techniques: Clinical Proteomics, Derivative Assay, Binding Assay, Incubation, Flow Cytometry, Standard Deviation